IRELAnD – Investigating the role of early low-dose aspirin in diabetes: a phase III multicentre double-blinded, placebo-controlled randomised trial of low-dose aspirin initiated in the first trimester of diabetes pregnancy
- Principal Investigator: Prof. Fionnuala Breathnach
- Co-Investigator: Dr Karen Flood
- Sub-Investigator(s): Dr Catherine Finnegan, Dr Sarah Nicholson
- Trial Coordinator: Denisa Asandei
This is a multicentre randomised conrtolled trial investigating the role of aspirin in pregnancy outcomes of women with pre-gestational diabetes. The trial is led by the Rotunda Hospital and is also recruiting patients at The Coombe Women & Infants University Hospital, National Maternity Hospital, Our Lady of Lourdes Hospital Drogheda, Galway University Hospital and Cork University Maternity Hospital.
HOME INDUCTION – A randomised open-label trial to assess outpatient induction of labour and compare efficacy of Propess vs Dilapan-S® for induction of labour at 39 weeks’ gestation in normal risk nulliparous women.
- Principal Investigator: Prof. Fergal Malone
- Co-Investigator: Dr Sarah Nicholson
- Trial Coordinator: Sirisha Bellamkonda
A randomised open-label trial to assess different methods of outpatient induction of labour and compare the efficacy of a prostaglandin vaginal insert (Propess) versus a non-pharmacologic cervical dilator (Dilapan) for induction of labour at 39 weeks’ gestation in normal risk nulliparous women.
PIPELLE – Is pipelle biopsy of benefit in patients with postmenopausal bleeding and atrophic-appearing cavity?
Principal Investigator: Dr Naomi Burke
Co-Investigator: Dr Liz Tunney
Trial Co-ordinator: Denisa Asandei
A single site RCT to investigate whether the Pipelle endometrial sampling device is of benefit in patients with postmenopausal bleeding and an atrophic-appearing uterine cavity. Differences in pain scores, cost saving and differences in clinical follow up will be assessed to evaluate the benefit of Pipelle biopsy in patients with PMB and atrophic-appearing cavity.
PARTUM – Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
Principal Investigator: Prof Jennifer Donnelly
Trial Co-ordinator: Sirisha Bellamkonda
A pilot trial to determine whether low-dose aspirin (ASA) is efficacious and safe at preventing postpartum venous thromboembolism (VTE) in women at increased risk of VTE, compared to placebo.
ACEDUCT – Co-administration of Acetaminophen with Ibuprofen to Improve Duct Related Outcomes in Extremely Premature Infants.
Principal Investigator: Prof Afif El-Khuffash
Co-Investigator: Dr Rachel Mullaly
To evaluate the clinical impact, efficacy and safety of combination regime [Ibuprofen + Acetaminophen] for first treatment course for significant PDA in extremely low gestational age neonates (ELGANs) vs. Ibuprofen alone.
PROTECT - Pentoxifylline to improve long-term outcomes in preterm infants with late-onset sepsis or necrotizing enterocolitis.
Principal Investigator (Rotunda site): Prof Afif El-Khuffash
The aim of PROTECT is to investigate whether intravenous pentoxyfylline (PTX) versus placebo increase survival without disability at 24 months of age in infants born at less than 29 weeks gestation with late onset sepsis or necrotising enterocolitis.